SINGAPORE, March 20, 2026 \u2014 A recent
\npreclinical study has reported that the combination of atorvastatin and Cuban
\npolicosanol may offer enhanced lipid profile modulation compared to
\natorvastatin alone. The findings were published in the latest issue of the
\nSCI-indexed journal Pharmaceuticals.<\/p>\n
Statins remain a
\nwidely used standard approach for managing cholesterol levels globally.
\nHowever, ongoing research continues to explore complementary strategies that
\nmay support lipid metabolism and overall physiological balance during long-term
\nuse.<\/p>\n
In this 12-week
\nstudy, researchers used a zebrafish model induced with hyperlipidemia and
\nhyperglycemia to evaluate the effects of atorvastatin, Cuban policosanol, and
\ntheir combination. A total of 112 zebrafish were divided into four groups:
\ncontrol, atorvastatin-only, policosanol-only, and combination consumption.<\/p>\n
The results showed
\nthat the combination group demonstrated a greater reduction in total
\ncholesterol, triglycerides, and LDL cholesterol compared to the atorvastatin-only
\ngroup. In addition, HDL cholesterol
\nlevels significantly
\nincreased by 1.3-fold in the combination group compared to the control group. HDL cholesterol is
\ncommonly referred to as \u201cgood cholesterol\u201d due to its role in supporting cardiovascular
\nhealth.<\/p>\n
The study also
\nreported changes in several biological markers. The combination group showed
\nreduced levels of inflammatory indicators in liver tissue and changes in
\nmarkers associated with lipid accumulation. In brain and retinal tissues,
\nmarkers related to inflammation and cellular aging were also observed to be
\nlower in the combination group.<\/p>\n
Dr. Kyung Hyun Cho,
\nthe lead researcher of the study, commented, \u201cThese findings suggest that Cuban
\npolicosanol, when used in combination with statins, may offer complementary
\neffects in lipid metabolism and related biological processes.\u201d<\/p>\n
The full study is available online at: https:\/\/www.mdpi.com\/1424-8247\/19\/2\/237<\/a><\/p>\n